P-Anisidine → N-(4-methoxyphenyl)-3-methyl-4-nitrobenzamide

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1.[CH3:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[N+:20]([O-:22])=[O:21])[C:14](O)=[O:15]>>[CH3:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][C:19]=1[N+:20]([O-:22])=[O:21])[C:14]([NH:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:15]

참가 물질

반응물 2

HCID 7732P-Anisidine

HCID 183703-Methyl-4-nitrobenzoic acid

생성물 1

HCID 790964N-(4-methoxyphenyl)-3-methyl-4-nitrobenzamide수율 93%

실험 절차

Using p-anisidine (738 mg, 6.0 mmol) and 3-methyl-4-nitrobenzoic acid (906 mg, 5.0 mmol), the procedure of Reference Example 16 was repeated to obtain 1.33 g (93.0%) of the title compound in the form of yellow powder.

출처 및 근거

ORD 기록: ord-0bbf02c3b9c74d45aad453e8f1838747
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05728835

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