Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Erlotinib Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Erlotinib | HCID 176870 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Erlotinib Hydrochloride | HCID 176871 | 97.2% |
반응 단계
10.0 g crystal form IV of erlotinib base was added to 200 ml 1,4-dioxane, heated to dissolve until being clarified, 6.4 g isopropanol saturated with HCl gas was added dropwise at 60-70° C., after dripping, stirred for 30 minutes while maintaining the temperature, stirred for 1 hour at 0-15° C. before filtration, dried at 50° C. to obtain 10.6 g sample of crystal form A. The yield was 97.2% and the purity was 99.8% (by HPLC).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653264B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-6190bf32fedb433b972574d6bf7167e2 |
| 출처 메모 | uspto-grants-2014_02 |