Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethyl-4-hydroxybenzonitrile → 4-[(2,6-Dichloropyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethyl-4-hydroxybenzonitrile | HCID 20176 | — |
| 반응물 | 2,4,6-Trichloropyrimidine | HCID 77378 | — |
| 반응물 | Etravirine | HCID 193962 | — |
| 생성물 | 4-[(2,6-Dichloropyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile | HCID 49757563 | — |
반응 단계
WO 2010150279 describes a process for the formation of Etravirine, comprising condensation of 2,4,6-trichloropyrimidine with 3,5-dimethyl-4-hydroxybenzonitrile to give 4-[(2,6-dichloro)-4-pyrimidinyloxy]-3,5-dimethyl benzonitrile, which is condensed with 4-aminobenzonitrile. Aminolysis of the resulting compound followed by halogenation gives Etravirine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653266B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-ae122e317d6c493fbe51d722b0d90d3e |
| 출처 메모 | uspto-grants-2014_02 |