p-Toluenesulfonic acid → N,N-dimethyl-2-(4-oxocyclohexyl)acetamide
반응식
C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:12][N:13]([CH3:27])[C:14](=[O:26])[CH2:15][CH:16]1[CH2:25][CH2:24][C:19]2(OCC[O:20]2)[CH2:18][CH2:17]1>CC(C)=O>[CH3:27][N:13]([CH3:12])[C:14](=[O:26])[CH2:15][CH:16]1[CH2:25][CH2:24][C:19](=[O:20])[CH2:18][CH2:17]1참가 물질
4
실험 절차
p-Toluenesulfonic acid (84 mg) is added to a solution of N,N-dimethyl-2-(1,4-dioxaspiro[4.5]decan-8-yl)acetamide (500 mg) in acetone (10 ml) and the mixture is heated under reflux for 3 hours. The solvent is removed under reduced pressure. The residue is dissolved in CH2Cl2 and washed with water. The organic layer is dried (Na2SO4) and filtered, and the solvent is removed under reduced pressure to give N,N-dimethyl-2-(4-oxocyclohexyl)acetamide (400 mg).
후처리
- temperaturethe mixture is heated
- temperatureunder reflux for 3 hours
- customThe solvent is removed under reduced pressure
- dissolutionThe residue is dissolved in CH2Cl2
- washwashed with water
- dry with materialThe organic layer is dried (Na2SO4)
- filtrationfiltered
- customthe solvent is removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-51a304ae37d4451fb65828b5bd44e609
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08653262B2
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