Diethylamine → methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate

참여 물질

역할	이름	HCID	투입량
반응물	Diethylamine	HCID 8021	—
반응물	Bis(4-nitrophenyl) carbonate	HCID 78756	—
반응물	methyl(2S)-2-[(2-{[(9H-fluoren-9-ylmethoxy)Carbonyl][(1-methyl-1H-benzimidazol-2-yl)methyl]amino}ethyl)amino]-3,3-dimethylbutanoate	HCID 66891668	—
용매	Dimethylformamide	HCID 6228	—
용매	1,1-Dichloroethane	HCID 6365	—
생성물	methyl(2S)-3,3-dimethyl-2-{3-[(1-methyl-1H-benzimidazol-2-yl)methyl]-2-oxoimidazolidin-1-yl}butanoate	HCID 66890629	65.2%

반응 조건

온도	25 °C

반응 단계

A solution of the product of Example 148D (0.19 g) in N,N-dimethylformamide (3.5 mL) was treated with diethylamine (0.35 mL), stirred at 25° C. for 1.5 hours and concentrated. A solution of the residue in dichloroethane (7 mL) was treated with bis-(p-nitrophenyl) carbonate (0.128 g, 1.2 equivalents), stirred at 60° C. for 16 hours and concentrated. The residue was chromatographed on silica gel, eluting with ethyl acetate:dichloromethane (3:2) to give 80 mg (64%) of the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08653141B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-f275c48d35fd4f29a700320587dd4070
출처 메모	uspto-grants-2014_02