(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol → (3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

HRID 243797노트

반응식

HRID 243797 반응식
[C:1]([C:5]1[CH:6]=[C:7]([N+:15]([O-])=O)[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[NH2:15][C:7]1[C:8]([O:13][CH3:14])=[C:9]([CH2:11][OH:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=1

참가 물질

4

반응물 1

HCID 58493934(5-Tert-butyl-2-methoxy-3-nitrophenyl)methanol

생성물 1

HCID 58366895(3-Amino-5-tert-butyl-2-methoxyphenyl)methanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of (5-tert-butyl-2-methoxy-3-nitrophenyl)methanol (0.250 g, 1.04 mmol) in ethyl acetate (10.4 mL), 10% palladium/activated charcoal (0.025 g) was added and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 14 hours. After completion of the reaction, insoluble materials were filtered through a Celite pad, and the solvent was washed with ethyl acetate. The solvent of the filtrate was evaporated under reduced pressure to obtain 0.219 g (quantitative) of the crude product containing the captioned compound.

후처리

  1. customAfter completion of the reaction, insoluble materials
  2. filtrationwere filtered through a Celite pad
  3. washthe solvent was washed with ethyl acetate
  4. customThe solvent of the filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b3b8e79bbc504cba9f693ebbff4c6a6a
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653304B2

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