Water → 5-(2-Chloroethyl)Oxindole

HRID 24380노트

반응식

HRID 24380 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=O.C([SiH](CC)CC)C.O>FC(F)(F)C(O)=O>[Cl:1][CH2:2][CH2:3][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2

참가 물질

5

반응물 3

HCID 962WaterHCID 12052TriethylsilaneHCID 20605765-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 145813925-(2-Chloroethyl)Oxindole수율 65%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 5-chloroacetyl-2-oxindole (4.18 g) in trifluoroacetic acid (30 ml) was cooled in an ice bath and 4.65 g of triethylsilane added. The mixture was then stirred at room temperature for 3 hours. The mixture was poured into 150 ml of water and the precipitate which formed was collected by vacuum filtration, washed with 50 ml of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.

후처리

  1. customthe precipitate which formed
  2. filtrationwas collected by vacuum filtration
  3. washwashed with 50 ml of water
  4. customdried

출처 및 근거

ORD 기록
ord-5e8a1e2bb0f9481c9e511871bbe592ce
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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