5-Fluoro-2-iodobenzoic acid → 2-(2H-1,2,3-Triazol-2-yl)benzoic acid

HRID 243825

반응식

HRID 243825 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].F[C:17]1[CH:18]=[CH:19][C:20](I)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23]>>[N:12]1[N:11]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:10][C:6]=2[C:7]([OH:9])=[O:8])[N:15]=[CH:14][CH:13]=1.[N:12]1([C:20]2[CH:19]=[CH:18][CH:17]=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH:13]=[CH:14][N:15]=[N:11]1

참가 물질

4

반응물 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

생성물 2

HCID 213135922-(2H-1,2,3-Triazol-2-yl)benzoic acidHCID 230237632-(1H-1,2,3-Triazol-1-yl)benzoic acid

실험 절차

The title compound was prepared in a manner analogous to Intermediate 1, substituting 2-iodobenzoic acid for 5-fluoro-2-iodo-benzoic acid. Two products were formed in this reaction, 2-[1,2,3]triazol-2-yl-benzoic acid and 2-[1,2,3]triazol-1-yl-benzoic acid, as a result of the tautomeric forms of 1,2,3-triazole. 1H NMR (400 MHz, CD3OD): 7.91 (s, 2H), 7.85-7.82 (m, 1H), 7.75 (dd, J=8.1, 1.0 Hz, 1H), 7.69 (td, J=7.7, 1.5 Hz, 1H), 7.60-7.55 (m, 1H).

출처 및 근거

ORD 기록
ord-97f2167f7f0b45afbbaa731eb57afaf1
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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