2-Iodo-5-methylbenzoic acid → 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

HRID 243829

반응식

HRID 243829 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].I[C:17]1C=CC(C)=CC=1C(O)=O.FC1C=CC(I)=C(C=1)C(O)=O>>[CH3:17][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 3

HCID 1429412-Iodo-5-methylbenzoic acidHCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

생성물 1

HCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

실험 절차

The title compound was prepared in a manner analogous to Intermediate 1, substituting for 2-iodo-5-methyl benzoic acid for 5-fluoro-2-iodo-benzoic acid in Step A. 1H NMR (400 MHz, CD3OD): 7.87 (s 2H), 7.66 (d, J=1.3 Hz, 1H), 7.59 (d, J=8.2 Hz, 1H), 7.53-7.46 (m, 1H), 2.45 (s, 3H).

출처 및 근거

ORD 기록
ord-cbfbc63ea2ae4cec929f57e9d7820e4b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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