Trifluoroacetic acid → 5-Ethyl-1,3-dihydro-2H-indol-2-one

HRID 24384

반응식

HRID 24384 반응식
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)(=O)[CH3:2].FC(F)(F)C(O)=O.C([SiH](CC)CC)C>>[CH2:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)[CH3:2]

참가 물질

4

반응물 3

HCID 6422Trifluoroacetic acidHCID 12052Triethylsilane2회HCID 102196435-acetyl-2,3-dihydro-1H-indol-2-one

생성물 1

HCID 101541895-Ethyl-1,3-dihydro-2H-indol-2-one수율 71%

실험 절차

5-Acetyl-2-oxindole (2 g) and 15 ml of trifluoroacetic acid in an ice bath was slowly treated with 1.8 g of triethylsilane and then stirred at room temperature for 5 hours. One ml of triethylsilane was added and stirring continued overnight. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of 5-ethyl-2-oxindole as a yellow solid.

후처리

  1. stirringstirring continued overnight
  2. filtrationthe resulting precipitate collected by vacuum filtration
  3. washwashed copiously with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-c8e3e385743e4295901d90ded8b42ade
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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