Benzoic acid, 2-bromo-5-fluoro-, methyl ester → methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate

HRID 243849

반응식

HRID 243849 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[NH:13]1[C:17](B(O)O)=[CH:16][CH:15]=[N:14]1.C([O-])(O)=O.[Na+]>COCCOC.O>[F:12][C:9]1[CH:10]=[CH:11][C:2]([C:15]2[NH:14][N:13]=[CH:17][CH:16]=2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

6

반응물 3

HCID 138875Benzoic acid, 2-bromo-5-fluoro-, methyl esterHCID 516892Sodium BicarbonateHCID 112519791H-Pyrazole-5-boronic acid

생성물 1

HCID 67086678methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate수율 44.9%

시약·촉매·용매 2

HCID 962Water용매HCID 80711,2-Dimethoxyethane용매

반응 조건

온도
23 °C

실험 절차

Methyl 2-bromo-5-fluorobenzoate (1.0 g, 4.2 mmol) and (1H-pyrazol-5-yl)boronic acid (485 mg, 4.6 mmol) were combined and dissolved in degassed DME (15 ml) then treated with NaHCO3 (706 mg, 8.4 mmol) in water and the reaction purged with bubbling N2 for 5 minutes. The reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol) and then purged with bubbling for 5 minutes in a sealed vessel and then heated to reflux for 2 h. The reaction mixture was cooled to 23° C., filtered, and solid rinsed with EtOAc. The organic layers were separated, dried and concentrated. Purification via FCC (ethyl acatate/hexanes, 0-30%) afforded methyl 5-fluoro-2-(1H-pyrazol-5-yl)benzoate (415 mg, 44%).

후처리

  1. customthe reaction purged with bubbling N2 for 5 minutes
  2. additionThe reaction was treated with Pd(PPh3)4 (243 mg (0.2 mmol)
  3. custompurged
  4. customwith bubbling for 5 minutes in a sealed vessel
  5. temperatureheated
  6. temperatureto reflux for 2 h
  7. filtrationfiltered
  8. washsolid rinsed with EtOAc
  9. customThe organic layers were separated
  10. customdried
  11. concentrationconcentrated
  12. customPurification via FCC (ethyl acatate/hexanes, 0-30%)

출처 및 근거

ORD 기록
ord-bb7166fd3d904c0d84d22df8de72cb8c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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