2,4-Dichloro-5-fluoropyrimidine → 2-Chloro-5-fluoro-4,6-dimethylpyrimidine

HRID 243866노트

반응식

HRID 243866 반응식
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([F:9])=[CH:4][N:3]=1.Cl[C:11]1N=C(Cl)C(F)=CN=1>>[Cl:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([F:9])=[C:6]([CH3:8])[N:7]=1

참가 물질

3

반응물 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 207780732-Chloro-5-fluoro-4-methylpyrimidine

생성물 1

HCID 866688392-Chloro-5-fluoro-4,6-dimethylpyrimidine

실험 절차

2-Chloro-5-fluoro-4,6-dimethylpyrimidine was prepared in a manner analogous to Intermediate 55, substituting 2,4,6-trichloro-5-fluoropyrimidine for 2,4-dichloro-5-fluoropyrimidine. 1H NMR (500 MHz, CDCl3): 2.50 (d, J=2.7 Hz, 6H).

출처 및 근거

ORD 기록
ord-6bd54134d84542b9bd82e01df14fd3c9
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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