2-Chloro-6-methylnicotinic acid → 4-(1H-1,2,3-Triazol-1-yl)nicotinic acid

HRID 243872

반응식

HRID 243872 반응식
CC1C=CC(C(O)=O)=C([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)N=1.Cl[C:17]1[C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=[CH:19][CH:18]=1.ClC1N=C(C)C=CC=1C(O)=O>>[N:12]1([C:17]2[C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=[CH:19][CH:18]=2)[CH:13]=[CH:14][N:15]=[N:11]1

참가 물질

4

반응물 3

HCID 1217242-Chloro-6-methylnicotinic acidHCID 8182294-Chloronicotinic acidHCID 670868556-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid

생성물 1

HCID 670869954-(1H-1,2,3-Triazol-1-yl)nicotinic acid

실험 절차

The title compound was prepared in a manner analogous to Intermediate 70 substituting 4-chloronicotinic acid for 2-chloro-6-methylnicotinic acid. MS (ESI): mass calculated for C11H10N4O3, 246.22; m/z found 247.3 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.09 (t, J=2.8 Hz, 1H), 7.92-7.86 (m, 3H), 7.66 (dd, J=8.7, 3.3 Hz, 1H), 2.17 (dd, J=2.5, 1.3 Hz, 3H).

출처 및 근거

ORD 기록
ord-054d2835cdcf4e23818a1dde12a36f61
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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