2-Iodo-3-methylbenzoic acid → 3-Methyl-2-(1H-pyrazol-1-YL)benzoic acid

HRID 243883

반응식

HRID 243883 반응식
F[C:2]1[C:3]([N:11]2[CH:15]=[CH:14][CH:13]=[N:12]2)=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:16]C1C(I)=C(C=CC=1)C(O)=O.FC1C(I)=C(C=CC=1)C(O)=O>>[CH3:16][C:2]1[C:3]([N:11]2[CH:15]=[CH:14][CH:13]=[N:12]2)=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6]

참가 물질

4

실험 절차

The title compound was prepared in a manner analogous to Intermediate 93 substituting 3-methyl-2-iodobenzoic acid for 3-fluoro-2-iodobenzoic acid. 1H NMR (500 MHz, CDCl3): 7.79 (d, J=7.4 Hz, 2H), 7.48 (d, J=7.5 Hz, 1H), 7.42 (t, J=7.6 Hz, 1H), 6.53 (s, 1H), 2.07 (s, 3H).

출처 및 근거

ORD 기록
ord-f9942c686608430dbd22ba8f57fdccb5
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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