Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 24390생성일: 2026년 10월 26일
Piperidine → N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide
https://huagongshe.com/reaction/24390
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-carbaldehyde | HCID 1797751 | — |
| 반응물 | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide | HCID 57040241 | 44.2% |
반응 단계
A mixture of 6-acetamido-2-oxindole (285 mg), 2,2-dimethylchroman-6-carboxaldehyde (285 mg) and piperidine (0.2 ml) was stirred at 90° C. overnight. The reaction mixture was cooled and diluted with 20 ml of water. The sticky solid which formed was filtered and chromatographed (2% ethanol in ethyl acetate) to give 240 mg (44%) of N-[3-(2,2-dimethylchroman-6-ylmethylene)-2-oxo-2,3-dihydro-1H-indol-6-yl]acetamide as an orange red solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06855730B2 |
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| 출처 데이터셋 | uspto-grants-2005_02 |
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| ORD ID | ord-01a3a2ad64bf410eb46cf49e157ea541 |
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| 출처 메모 | uspto-grants-2005_02 |
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