5-Fluoro-2-(pyrimidin-2-yl)benzoic acid → 2-(4,6-Dimethoxypyrimidin-2-yl)-5-[(5-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]octahydropyrrolo[3,4-c]pyrrole

참여 물질

역할	이름	HCID	투입량
반응물	5-Fluoro-2-(pyrimidin-2-yl)benzoic acid	HCID 67086950	—
반응물	2-(4,6-Dimethoxy-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole	HCID 67116491	—
생성물	2-(4,6-Dimethoxypyrimidin-2-yl)-5-[(5-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]octahydropyrrolo[3,4-c]pyrrole	HCID 52917464	—

반응 단계

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 39 and Intermediate 13. MS (ESI) mass calcd. for C23H23FN6O3, 450.18; m/z found, 451.1 [M+H]+. 1H NMR (CDCl3): 8.68 (d, J=4.9 Hz, 2H), 8.25 (dd, J=8.7, 5.5 Hz, 1H), 7.28-7.15 (m, 2H), 7.12 (dd, J=8.6, 2.5 Hz, 1H), 5.31 (s, 1H), 3.84-3.65 (m, 7H), 3.63-3.33 (m, 5H), 3.13-2.86 (m, 4H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08653263B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-9b62ec5d60884c75b85551d3493e9240
출처 메모	uspto-grants-2014_02