2-(4-Trifluoromethyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole → 2-[(5-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-5-[4-(trifluoromethyl)pyrimidin-2-yl]octahydropyrrolo[3,4-c]pyrrole

HRID 243972

반응식

HRID 243972 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[CH2:16][CH:15]3[CH:11]([CH2:12][NH:13][CH2:14]3)[CH2:10]2)[N:4]=1.[F:19][C:20]1[CH:21]=[CH:22][C:23]([C:29]2[N:34]=[CH:33][CH:32]=[CH:31][N:30]=2)=[C:24]([CH:28]=1)[C:25](O)=[O:26]>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([C:29]2[N:30]=[CH:31][CH:32]=[CH:33][N:34]=2)=[C:24]([C:25]([N:13]2[CH2:14][CH:15]3[CH:11]([CH2:10][N:9]([C:5]4[N:4]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:8]=[CH:7][N:6]=4)[CH2:16]3)[CH2:12]2)=[O:26])[CH:28]=1

참가 물질

3

반응물 2

HCID 609172242-(4-Trifluoromethyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrroleHCID 670869505-Fluoro-2-(pyrimidin-2-yl)benzoic acid

생성물 1

HCID 671165162-[(5-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-5-[4-(trifluoromethyl)pyrimidin-2-yl]octahydropyrrolo[3,4-c]pyrrole

실험 절차

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 33 and Intermediate 13. MS (ESI): mass calculated for C22H18F4N6O, 459.42; m/z found 459.1 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.74 (d, J=4.9, 2H), 8.60-8.28 (m, 2H), 7.23-7.04 (m, 3H), 6.84-6.75 (m, 1H), 4.03-2.97 (m, 10H).

출처 및 근거

ORD 기록
ord-c6f84ec26b84416794cee86826efff94
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653263B2

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