Acetic Acid → 7-Azaoxindole acetic acid salt

HRID 24401노트

반응식

HRID 24401 반응식
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]1=[O:11].[C:13]([OH:16])(=[O:15])[CH3:14]>C(#N)C.[Zn]>[C:13]([OH:16])(=[O:15])[CH3:14].[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][N:6]=2)[CH2:2][C:3]1=[O:11]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 138640943,3-Dibromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

생성물 1

HCID 219257347-Azaoxindole acetic acid salt수율 91%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 6342Acetonitrile용매

실험 절차

Zinc dust (6.5 g) was added to a solution of 3,3-dibromo-7-azaoxindole (2.9 g) in acetic acid (20 ml) and acetonitrile (30 ml). The mixture was stirred for 2 hours at room temperature. The solids were removed by filtration and the solvent evaporated. The residue was treated with ethyl acetate. The ethyl acetate solution containing insoluble solid was passed through a short column of silica gel. The collected ethyl acetate solution was evaporated and the residue dried under vacuum to give 1.8 g (91% yield) of 7-aza-2-oxindole acetic acid salt.

후처리

  1. customThe solids were removed by filtration
  2. customthe solvent evaporated
  3. additionThe residue was treated with ethyl acetate
  4. additionThe ethyl acetate solution containing insoluble solid
  5. customThe collected ethyl acetate solution was evaporated
  6. customthe residue dried under vacuum

출처 및 근거

ORD 기록
ord-72dacf05edc84f9095ba6d710f037b89
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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