Sodium Carbonate → 2-(3-Methoxyphenyl)-4,5-dimethoxybenzaldehyde

HRID 24413

반응식

HRID 24413 반응식
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][C:6]([CH:7]=[O:8])=[C:5](Br)[CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH3:20][O:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1>C1(C)C=CC=CC=1.C(O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:20][O:21][C:22]1[CH:27]=[C:26]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:10]([O:11][CH3:12])=[CH:9][C:6]=2[CH:7]=[O:8])[CH:25]=[CH:24][CH:23]=1

참가 물질

7

반응물 3

HCID 10340Sodium CarbonateHCID 793516-Bromo-3,4-dimethoxybenzaldehydeHCID 2734370(3-Methoxyphenyl)boronic acid

생성물 1

HCID 225710312-(3-Methoxyphenyl)-4,5-dimethoxybenzaldehyde수율 98%

시약·촉매·용매 3

HCID 178418397HCID 178418397, 화합물촉매HCID 702Ethanol용매HCID 1140Toluene용매

실험 절차

Tetrakis(triphenylphosphine)palladium(0) (0.36 g) was added to a solution of 4,5-dimethoxy-2-bromobenzaldehyde (2.5 g) in toluene (20 ml) and ethanol (20 ml), followed by addition of 2M aqueous sodium carbonate (20 ml). To this mixture was added 3-methoxyphenylboronic acid (1.7 g), and the mixture was heated to reflux. After 1 hour, the reaction was partitioned between water (150 ml) and ethyl acetate (300 ml). The organic layer was washed with saturated aqueous sodium bicarbonate (150 ml) and brine (150 ml), dried over magnesium sulfate and concentrated. Chromatography (silica, 20-30-40% ethyl acetate/hexanes) afforded 2.7 g (98%) of 2-(3-methoxyphenyl)-4,5-dimethoxybenzaldehyde as a yellow oil which solidified upon standing.

후처리

  1. temperaturethe mixture was heated to reflux
  2. customthe reaction was partitioned between water (150 ml) and ethyl acetate (300 ml)
  3. washThe organic layer was washed with saturated aqueous sodium bicarbonate (150 ml) and brine (150 ml)
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ed482061e220479d8ec3892c16a689e8
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855730B2

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