Methanol → HCID 58241680, 화합물

HRID 244326노트

반응식

HRID 244326 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[C:3]=1[I:12].[CH3:13][O-:14].[Na+].[CH3:16][OH:17]>>[I:12][C:3]1[C:4]([O:14][CH3:13])=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[O:17][CH3:16]

참가 물질

4

반응물 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 582416821,3-difluoro-2-iodo-4-nitrobenzene

생성물 1

HCID 58241680HCID 58241680, 화합물

실험 절차

1,3-Difluoro-2-iodo-4-nitrobenzene (5.0 g, 17.5 mmol) was dissolved in 50 ml of methanol, and NaOMe (3.79 g, 70.1 mmol) was added. The solution was heated under reflux for 16 h. After concentration, the residue was chromatographed on silica gel using petroleum ether/ethyl acetate. This gave 2-iodo-1,3-dimethoxy-4-nitrobenzene (3 g) as a yellowish powder.

후처리

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 16 h
  3. concentrationAfter concentration
  4. customthe residue was chromatographed on silica gel

출처 및 근거

ORD 기록
ord-0c6fb4f4265c412494ee9877da64758b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658569B2

반응 노트

불러오는 중…