Sodium Azide → 4-(2-Azidoacetyl)benzonitrile

HRID 244586

반응식

HRID 244586 반응식
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[N-:13]=[N+:14]=[N-:15].[Na+]>CO>[N:13]([CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4])=[N+:14]=[N-:15]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 986544-(Bromoacetyl)benzonitrile

생성물 1

HCID 586617294-(2-Azidoacetyl)benzonitrile수율 94%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the commercially available 4-bromoacetyl-benzonitrile (5 g, 22.32 mmol) in 150 mL of methanol was added sodium azide (1.74 g, 26.78 mmol) and the contents stirred at room temperature for 2 h. After removal of the solvent, the residue was treated with water (50 mL) and extracted with dichloromethane (3×50 mL). The combined organic layers were dried over MgSO4 and concentrated to give a yellow solid (3.90 g, 94%). This compound was used for the next step without any further purification.

후처리

  1. customAfter removal of the solvent
  2. additionthe residue was treated with water (50 mL)
  3. extractionextracted with dichloromethane (3×50 mL)
  4. dry with materialThe combined organic layers were dried over MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b2c5886bde8446999e9f1ed768a4f001
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658659B2

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