Thionyl Chloride → 2-Methyl-1,3-thiazole-4-carbonyl chloride

반응식

[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.S(Cl)([Cl:12])=O>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([Cl:12])=[O:9])[N:6]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride3회

HCID 2847282-Methyl-1,3-thiazole-4-carboxylic acid

생성물 1

HCID 211839592-Methyl-1,3-thiazole-4-carbonyl chloride

반응 조건

온도: 80 °C

실험 절차

To 2-methyl-1,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80° C. for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80° C. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound (1.12 g) as a brown solid

후처리

temperaturethe mixture heated for 2 h at 80° C
temperaturethe mixture heated for 2 h
concentrationThe mixture was concentrated in vacuo
customazeotroped with toluene

출처 및 근거

ORD 기록: ord-2fb1615a50a147d0bb6227abf6a7eaa2
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08658635B2

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