Thionyl Chloride → 1-Isopropyl-1H-pyrazole-5-carbonyl chloride

HRID 244685노트

반응식

HRID 244685 반응식
S(Cl)([Cl:3])=O.[CH3:5][CH:6]([N:8]1[C:12]([C:13]([OH:15])=O)=[CH:11][CH:10]=[N:9]1)[CH3:7]>>[CH3:5][CH:6]([N:8]1[C:12]([C:13]([Cl:3])=[O:15])=[CH:11][CH:10]=[N:9]1)[CH3:7]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 31509471-(propan-2-yl)-1H-pyrazole-5-carboxylic acid

생성물 1

HCID 583564221-Isopropyl-1H-pyrazole-5-carbonyl chloride

반응 조건

온도
80 °C

실험 절차

Thionyl chloride (5 ml) was added to 1-(1-methylethyl)-1H-pyrazole-5-carboxylic acid (1 g) and the reaction was heated at 80° C. for 5 h. The reaction was evaporated, then azeotroped with toluene to give title compound, 856 mg.

후처리

  1. customThe reaction was evaporated
  2. customazeotroped with toluene

출처 및 근거

ORD 기록
ord-270bd04e4d5e40fc80dfaf99e709ba8c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658635B2

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