Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 반응물 | 5-acetyl-2,3-dihydro-1H-indol-2-one | HCID 10219643 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 53819303 | 75% |
반응 단계
A mixture of 5-acetyl-2-oxindole (70 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was held in a sealed tube at 90° C. overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum to give 83 mg (75% yield) of 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855730B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-0d1f5f5413b047e993118d1e8df8d3b2 |
| 출처 메모 | uspto-grants-2005_02 |