Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 5-bromo-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Indole-2-carboxaldehyde | HCID 96389 | — |
| 반응물 | 5-Bromo-2-oxindole | HCID 611193 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-bromo-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | HCID 54268045 | — |
반응 단계
A mixture of 5-bromo-2-oxindole (212 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 5-bromo-3-(1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855730B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-5248c7e7e0b046bd8a8ebef9d912684b |
| 출처 메모 | uspto-grants-2005_02 |