Ethanol → Ethyl 2-(4-hexylphenyl)acetate

HRID 244933노트

반응식

HRID 244933 반응식
[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].S(=O)(=O)(O)O.[CH2:22](O)[CH3:23]>>[CH2:1]([C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14]([O:16][CH2:22][CH3:23])=[O:15])=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 20634302-(4-Hexylphenyl)acetic acid

생성물 1

HCID 3703215Ethyl 2-(4-hexylphenyl)acetate

반응 조건

온도
60 °C

실험 절차

5.5 g (25 mmol) of 2-(4-hexylphenyl)acetic acid was dissolved in 11 mL of ethanol and mixed with 1.1 g (11.2 mmol) of sulfuric acid and stirred at 60° C. for 1 hour. The reaction was quenched with cold saturated aqueous sodium carbonate (100 ml), and the reaction solution was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give 5.68 g of the desired product as a pale yellow oil.

후처리

  1. customThe reaction was quenched with cold saturated aqueous sodium carbonate (100 ml)
  2. extractionthe reaction solution was extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1106d78e57ec404380b319f778b70f45
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658686B2

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