Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 244971생성일: 2026년 10월 25일
Triethylamine → 4-[3-(4-Methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
https://huagongshe.com/reaction/244971
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile | HCID 11615540 | — |
| 반응물 | 2-Methyl-2-[(4-methylphenyl)amino]propanenitrile | HCID 21239243 | — |
| 반응물 | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[3-(4-Methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile | HCID 15951818 | 17% |
반응 단계
Triethylamine (0.101 g, 1 mmol) was added to a solution of 1a (0.456 g, 2 mmol) and 5a (0.348 g, 2 mmol) in dry THF (3 ml). The reaction mixture was stirred at 0° C. for 2 days and then concentrated to yield a dark residue which was subjected to flash chromatography (dichloromethane/acetone, 95:5) to afford 4-[3-(4-methylphenyl)-5-imino-4,4-dimethyl-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile, 5b (0.136 g, 0.34 mmol, 17%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08658681B2 |
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| 출처 데이터셋 | uspto-grants-2014_02 |
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| ORD ID | ord-672fc72e07f74006bd18aeb2002a59bf |
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| 출처 메모 | uspto-grants-2014_02 |
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