참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Chloro-6-methoxypyridine-4-carboxylic acid | HCID 2782124 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | Methyl 2-chloro-6-methoxyisonicotinate | HCID 13339618 | — |
반응 단계
To a suspension of 2-chloro-6-methoxy-isonicotinic acid (244 g, 1.30 mol) in methanol (2.5 L), H2SO4 (20 mL) is added. The mixture is stirred at reflux for 24 h before it is cooled to 0° C. The solid material is collected, washed with methanol (200 mL) and water (500 mL) and dried under HV to give 2-chloro-6-methoxy-isonicotinic acid methyl ester (165 g) as a white solid; LC-MS: tR=0.94 min, [M+1]+=201.89.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08658675B2 |
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| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-0a7cf0719f6146c0aaeb39853efd8457 |
|---|
| 출처 메모 | uspto-grants-2014_02 |
|---|
