Ammonia → 2-Cyclopentyl-6-methoxy-isonicotinamide

HRID 245081노트

반응식

HRID 245081 반응식
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:5]=1.[NH3:18]>CO>[CH:12]1([C:6]2[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH3:11])[N:7]=2)[C:3]([NH2:18])=[O:2])[CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 674912832-Cyclopentyl-6-methoxy-isonicotinic acid methyl ester

생성물 1

HCID 674914362-Cyclopentyl-6-methoxy-isonicotinamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-cyclopentyl-6-methoxy-isonicotinic acid methyl ester (3.19 g, 13.6 mmol) in 7 N NH3 in methanol (50 mL) is stirred at 60° C. for 18 h. The solvent is removed in vacuo and the residue is dried under HV to give crude 2-cyclopentyl-6-methoxy-isonicotinamide (3.35 g) as a pale yellow solid; LC-MS**: tR=0.57 min, [M+1]+=221.38.

후처리

  1. customThe solvent is removed in vacuo
  2. customthe residue is dried under HV

출처 및 근거

ORD 기록
ord-4132c8f19a9b43069de519bf9172fc15
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658675B2

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