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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 245284생성일: 2026년 10월 25일

Tributyl(1-fluorovinyl)stannane → 6-Amino-2-(4-chloro-2-fluoro-5-methoxyphenyl)-5-vinylpyrimidine-4-carboxylic acid methyl ester

https://huagongshe.com/reaction/245284

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참여 물질

역할이름HCID투입량
반응물Tributyl(1-fluorovinyl)stannaneHCID 11823857—
반응물2-(4-Chloro-2-fluoro-3-(1-fluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 59126906—
반응물6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-(1-fluorovinyl)pyrimidine-4-carboxylic acid methyl esterHCID 59432106—
생성물6-Amino-2-(4-chloro-2-fluoro-5-methoxyphenyl)-5-vinylpyrimidine-4-carboxylic acid methyl esterHCID 59432134—

반응 단계

6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-(1-fluorovinyl) pyrimidine-4-carboxylic acid methyl ester (utilized tributyl-(1-fluorovinyl)stannane prepared according to the procedures found in Bull. Chem. Soc. Jpn. 2002, 75(11), 2497-2502) (Compound 9): 1H NMR (CDCl3) δ 7.67 (dd, 1H), 7.22 (dd, 1H), 5.52 (br s, 2H), 5.23 (dd, 1H), 4.9 (dd, 1H), 3.99 (d, 3H), 3.95 (s, 3H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08658791B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-351b9331819946959a257a45d01d87d0
출처 메모uspto-grants-2014_02