Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitrogen → (5S)-5-(Aminomethyl)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitrogen | HCID 947 | — |
| 반응물 | (S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one | HCID 11213668 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | (5S)-5-(Aminomethyl)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxazolidinone | HCID 10780199 | 93.1% |
반응 단계
(S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (0.95 g, 2 mmol) and 0.5 g of 10 wt % Pd—C were added to 20 mL acetone and the air was replaced with N2. The reaction stirred under 5 Mpa hydrogen at room temperature (25° C.) for 5 hours. Filtered and the solvent was evaporated to provide 0.55 g of white solid in 93% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658789B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-b84c9af834694565ac940682c03fe0d3 |
| 출처 메모 | uspto-grants-2014_02 |