2,2-Dimethoxypropane → HCID 67356722, 화합물

HRID 245373노트

반응식

HRID 245373 반응식
[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])C=C[C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]([O:17][CH3:18])(C)[CH3:15]>CCOCC.CC1C=CC(S(O)(=O)=O)=CC=1>[CH3:12][O:13][CH:14]([O:17][CH3:18])[C:15]1[CH:4]=[CH:3][C:2]([F:1])=[C:9]([F:10])[C:8]=1[F:11]

참가 물질

5

반응물 2

HCID 64952,2-DimethoxypropaneHCID 5192262,3,4-Trifluorobenzaldehyde

생성물 1

HCID 67356722HCID 67356722, 화합물수율 71.7%

시약·촉매·용매 2

HCID 6101p-Toluenesulfonic acid촉매HCID 3283Diethyl Ether용매

실험 절차

A solution of 2,3,4-trifluorobenzaldehyde (25 g, 156.16 mmol), 2,2-dimethoxypropane (58.1 ml, 468.48 mmol), and 4-methylbenzenesulfonic acid (0.269 g, 1.56 mmol) was stirred at room temperature overnight. The reaction mixture diluted with ether and washed successively with aq. sodium bicarbonate solution, water, and brine. The organic layer dried over sodium sulfate and concentrated. The residue wasdistilled under high vacuum to give the title compound (23.07 g, 71.7%).

후처리

  1. washwashed successively with aq. sodium bicarbonate solution, water, and brine
  2. dry with materialThe organic layer dried over sodium sulfate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ac8141f9b0d146089b64d53c6e1b46c8
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658641B2

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