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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 245390생성일: 2026년 10월 26일

1-Methyl-2-imidazolecarboxaldehyde → 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanol

https://huagongshe.com/reaction/245390

반응식

참여 물질

역할이름HCID투입량
반응물1-Methyl-2-imidazolecarboxaldehydeHCID 139575—
반응물(2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholineHCID 67359669—
반응물ButyllithiumHCID 178418339—
생성물5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanolHCID 131731210—

반응 단계

Starting material: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42), 1-methyl-imidazole-2-carbaldehyde and n-BuLi

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08658641B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-85cf89e197624021b342fbdc6e275468
출처 메모uspto-grants-2014_02