Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-methyl-1H-imidazole-5-carbaldehyde → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(1-methyl-1H-imidazol-5-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-methyl-1H-imidazole-5-carbaldehyde | HCID 573592 | — |
| 반응물 | (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine | HCID 67357593 | — |
| 반응물 | CID 53628100 | HCID 178418400 | — |
| 생성물 | {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(1-methyl-1H-imidazol-5-yl)methanol | HCID 86658060 | — |
반응 단계
Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl) silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine (Intermediate 3), 1-methyl-imidazole-5-carbaldehyde (116 mg, 1.06 mmol) and sec-butyllithium.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658641B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-da7bd4812dbe40c58ba29fc8d3ea4df9 |
| 출처 메모 | uspto-grants-2014_02 |