Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylthiazole-5-carboxaldehyde → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(4-methyl-1,3-thiazol-5-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylthiazole-5-carboxaldehyde | HCID 581339 | — |
| 반응물 | (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine | HCID 67357593 | — |
| 반응물 | CID 53628100 | HCID 178418400 | — |
| 생성물 | {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(4-methyl-1,3-thiazol-5-yl)methanol | HCID 86658061 | — |
반응 단계
Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine (Intermediate 3, 1.0 g, 2.02 mmol), 4-methyl-1,3-thiazole-5-carbaldehyde and sec-butyllithium
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658641B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-b34046ce0efa4d6aa4cd7f65cb181e4b |
| 출처 메모 | uspto-grants-2014_02 |