2,4-Dichloro-1,3-thiazole-5-carboxaldehyde → HCID 67357190, 화합물

HRID 245401

반응식

HRID 245401 반응식
[Si:1]([O:18][CH2:19][C:20]1[C:25]([N:26]2[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]2)=[C:24]([Cl:34])[C:23]([F:35])=[CH:22][N:21]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:36][C:37]1[S:38][C:39]([CH:43]=[O:44])=[C:40]([Cl:42])[N:41]=1>>[Si:1]([O:18][CH2:19][C:20]1[N:21]=[C:22]([CH:43]([C:39]2[S:38][C:37]([Cl:36])=[N:41][C:40]=2[Cl:42])[OH:44])[C:23]([F:35])=[C:24]([Cl:34])[C:25]=1[N:26]1[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]1)([C:14]([CH3:17])([CH3:15])[CH3:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 14886722,4-Dichloro-1,3-thiazole-5-carboxaldehydeHCID 67319975(2R,6S)-4-(2-((tert-Butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine2회

생성물 1

HCID 67357190HCID 67357190, 화합물

실험 절차

Starting materials: (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine (Intermediate 45) and 2,4-dichlorothiazole-5-carbaldehyde.

출처 및 근거

ORD 기록
ord-36ea3f290d3243bda8483fec05c959b9
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658641B2

연결된 노트

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