Methylamine → N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

HRID 2455

반응식

HRID 2455 반응식
Cl[CH2:2][C:3]1[CH:19]=[CH:18][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[O:8])=[CH:5][CH:4]=1.[CH3:20][NH2:21]>O1CCOCC1>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[NH:9][C:7](=[O:8])[C:6]1[CH:18]=[CH:19][C:3]([CH2:2][NH:21][CH3:20])=[CH:4][CH:5]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 196899684-Chloromethyl-N-(2-methoxyphenyl)benzamide

생성물 1

HCID 19690083N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

후처리

  1. customwas removed by evaporation
  2. additionthe resulting residue was diluted with methylene chloride (10 ml)
  3. dry with materialAfter drying on anhydrous sodium carbonate
  4. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-1e483b3adf244fe28b89df6ce80d81bc
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728835

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