Potassium Cyanide → 4-((2R,4S,4aS)-11-fluoro-2,4-dimethyl-2',4',6'-trioxo-2,2',3',4,4a,4',6,6'-octahydro-1H,1'H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-8-yl)pyrimidine-2-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Cyanide	HCID 9032	—
반응물	(2R,4S,4 aS)-11-fluoro-2,4-dimethyl-8-(2-(methylsulfonyl)pyrimidin-4-yl)-2,4,4a,6-tetrahydro-1H,1'H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(3'H)-trione	HCID 67431840	—
생성물	4-((2R,4S,4aS)-11-fluoro-2,4-dimethyl-2',4',6'-trioxo-2,2',3',4,4a,4',6,6'-octahydro-1H,1'H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-8-yl)pyrimidine-2-carbonitrile	HCID 45254029	—

반응 단계

Starting material: (2R,4S,4aS)-11-fluoro-2,4-dimethyl-8-(2-(methylsulfonyl)pyrimidin-4-yl)-2,4,4a,6-tetrahydro-1H,1′H-spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5′-pyrimidine]-2′,4′,6′(3′H)-trione (Example 169) and potassium cyanide.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08658641B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-4cc82b6188d4477495596b3572bc7cfd
출처 메모	uspto-grants-2014_02