Oxalyl chloride → Benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate

HRID 245685노트

반응식

HRID 245685 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([C:15]([OH:17])=O)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[Cl:21][C:15]([CH:13]1[CH2:14][N:11]([C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:12]1)=[O:17]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 109882141-[(Benzyloxy)carbonyl]azetidine-3-carboxylic acid

생성물 1

HCID 86674648Benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate수율 102.6%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid (21.25 mmol, 5 g) in dichloromethane (60 ml) under a nitrogen atmosphere were added N,N-dimethylformamide (1.063 mmol, 0.083 ml) and oxalyl chloride (2M solution in dichloromethane, 25.00 mmol, 12.5 ml). After stirring at room temperature for two hours the reaction mixture was concentrated in vacuo to give 5.53 gram of crude benzyl 3-(chlorocarbonyl)azetidine-1-carboxylate.

후처리

  1. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-2168f576f3204af9ab23bec4b2d50b4c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658794B2

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