1-Methyl-2-oxopiperidine-4-carboxylic acid → HCID 86674654, 화합물

반응식

Cl.[NH2:2][CH2:3][C:4]1[C:9]([Cl:10])=[N:8][CH:7]=[CH:6][N:5]=1.[CH3:11][N:12]1[CH2:17][CH2:16][CH:15]([C:18](O)=[O:19])[CH2:14][C:13]1=[O:21]>>[Cl:10][C:9]1[C:4]([CH2:3][NH:2][C:18]([CH:15]2[CH2:16][CH2:17][N:12]([CH3:11])[C:13](=[O:21])[CH2:14]2)=[O:19])=[N:5][CH:6]=[CH:7][N:8]=1

참가 물질

반응물 2

HCID 222654461-Methyl-2-oxopiperidine-4-carboxylic acid

HCID 42614233(3-Chloropyrazin-2-yl)methanamine hydrochloride

생성물 1

HCID 86674654HCID 86674654, 화합물수율 62%

실험 절차

2-Aminomethyl-3-chloropyrazine hydrochloride (content 77%; 5.36 mmol, 1.0 g) and 1-methyl-2-oxopiperidine-4-carboxylic acid (5.36 mmol, 0.843 g) were applied according to the procedure in example 13 step 13a and purified using column chromatography (silica gel; dichloromethane with 10% methanol) to give N-((3-chloropyrazin-2-yl)methyl)-1-methyl-2-oxopiperidine-4-carboxamide (940 mg).

후처리

custompurified

출처 및 근거

ORD 기록: ord-253886c950ab4ce69832388fef5e53af
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08658794B2

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