4-chloro-N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxamide → HCID 178487946, 화합물

HRID 245730

반응식

HRID 245730 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14](B3OC(C)(C)C(C)(C)O3)=[CH:13][C:12]=2[O:26][CH3:27])=[O:9])[N:5]([CH3:7])[CH:6]=1.Br[C:29]1[N:30]=[C:31]([C@H:39]2[CH2:44][CH2:43][C@H:42]([N:45]3[CH2:50][CH2:49][N:48]([CH3:51])[CH2:47][CH2:46]3)[CH2:41][CH2:40]2)[N:32]2[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[C:33]=12>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:29]3[N:30]=[C:31]([C@H:39]4[CH2:40][CH2:41][C@H:42]([N:45]5[CH2:46][CH2:47][N:48]([CH3:51])[CH2:49][CH2:50]5)[CH2:43][CH2:44]4)[N:32]4[CH:37]=[CH:36][N:35]=[C:34]([CH3:38])[C:33]=34)=[CH:13][C:12]=2[O:26][CH3:27])=[O:9])[N:5]([CH3:7])[CH:6]=1

참가 물질

3

반응물 2

HCID 673639734-chloro-N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxamideHCID 178432912HCID 178432912, 화합물

생성물 1

HCID 178487946HCID 178487946, 화합물수율 47.7%

실험 절차

Reaction of 4-chloro-N-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxamide (30 mg) and 1-bromo-8-methyl-3-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)imidazo[1,5-a]pyrazine (30 mg) according to the procedure described in example 4 step 4c and purification by column chromatography (silica gel; dichloromethane with gradient 0 to 20% of methanol) gave 4-chloro-N-(2-methoxy-4-(8-methyl-3-((trans)-4-(4-methylpiperazin-1-yl)cyclohexyl)imidazo[1,5-a]pyrazin-1-yl)phenyl)-1-methyl-1H-pyrrole-2-carboxamide (21 mg).

후처리

  1. customdescribed in example 4 step 4c and purification by column chromatography (silica gel; dichloromethane with gradient 0 to 20% of methanol)

출처 및 근거

ORD 기록
ord-eef651e3b70e4efca9f6aad7a201223d
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658794B2

연결된 노트

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