Trifluoroacetic acid → (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

HRID 245910노트

반응식

HRID 245910 반응식
C(OC(=O)[NH:7][C@H:8]([CH3:13])[C:9]([F:12])([F:11])[CH3:10])(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[F:11][C:9]([F:12])([CH3:10])[C@H:8]([NH2:7])[CH3:13]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86677920((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester

생성물 1

HCID 86677918(R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a round-bottomed flask, ((R)-2,2-difluoro-1-methyl-propyl)-carbamic acid tert-butyl ester (148 mg, 0.71 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.6 ml, 20.8 mmol) was slowly added. The reaction mixture was stirred at room temperature for 1.5 h then concentrated to give (R)-2,2-difluoro-1-methyl-propylamine trifluoroacetate as a light brown oil which was used without further purification.

후처리

  1. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-7543787c2f79473aa5d98a0a2c337a2a
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

반응 노트

불러오는 중…