Trifluoroacetic acid → HCID 86677924, 화합물
반응식
C(OC(=O)[NH:7][C@@H:8]([C:10](=[O:15])[NH:11][CH2:12][CH2:13][OH:14])[CH3:9])(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C@H:8]([CH3:9])[C:10]([NH:11][CH2:12][CH2:13][OH:14])=[O:15]참가 물질
4
실험 절차
In a round-bottomed flask, [(R)-1-(2-hydroxy-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (180 mg, 0.78 mmol) was dissolved in dichloromethane (5 ml) and trifluoroacetic acid (1.8 ml, 23.4 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2 h then concentrated to afford (R)-2-amino-N-(2-hydroxy-ethyl)-propionamide trifluoroacetate as a light yellow oil which was used without further purification.
후처리
- concentrationthen concentrated
출처 및 근거
- ORD 기록
- ord-a5a7c0e8d56c4b7c9bf4a465add0e46f
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08658646B2
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