Trifluoroacetic acid → [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

HRID 245940노트

반응식

HRID 245940 반응식
C(OC(=O)[NH:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9])(C)(C)C.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>ClCCl>[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21].[NH2:7][C@@H:8]([C:10]1[O:11][CH:12]=[C:13]([CH2:15][OH:16])[N:14]=1)[CH3:9]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68670262(R)-tert-butyl 1-(4-(hydroxymethyl)oxazol-2-yl)ethylcarbamate

생성물 1

HCID 71280113[2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a round-bottomed flask, [(R)-1-(4-hydroxymethyl-oxazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (137 mg, 0.51 mmol) was dissolved in dichloromethane (3 ml) and trifluoroacetic acid (1.2 ml, 15.6 mmol) was slowly added. The reaction was stirred at room temperature for 1.5 h then concentrated to afford [2-((R)-1-amino-ethyl)-oxazol-4-yl]-methanol trifluoroacetate as a brown oil which was used without further purification.

후처리

  1. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-c2524aa9dd504d68bc535e9ec978dcc4
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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