Pyrrolidine → ((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Pyrrolidine	HCID 31268	—
반응물	(R)-3-((tert-butoxycarbonyl)amino)butanoic acid	HCID 2761507	—
반응물	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
용매	Dimethylformamide	HCID 6228	—
생성물	((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester	HCID 71280091	—

반응 단계

To a solution of (R)-3-tert-butoxycarbonylamino-butyric acid (150 mg, 0.74 mmol) and HATU (309 mg, 0.81 mmol) in DMF (2 mL) was added pyrrolidine (0.19 mL, 2.21 mmol). The resultant yellow reaction mixture was stirred at room temperature overnight then quenched with water and extracted with EtOAc (2×). The combined organics were washed with water (3×) and brine then dried over MgSO4 and concentrated to afford ((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester as a colorless oil which was used without further purification.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08658646B2
출처 데이터셋	uspto-grants-2014_02
ORD ID	ord-1c7ca478f1694f36946f8e189de697d9
출처 메모	uspto-grants-2014_02