Trifluoroacetic acid → (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

HRID 245987

반응식

HRID 245987 반응식
C(OC(=O)[NH:7][C@H:8]([CH3:17])[CH2:9][C:10](=[O:16])[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>C(Cl)Cl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[CH2:9][C:10]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:16]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71280091((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester

생성물 1

HCID 71280224(R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of ((R)-1-methyl-3-oxo-3-pyrrolidin-1-yl-propyl)-carbamic acid tert-butyl ester (crude from step 1, 189 mg, 0.74 mmol) in CH2Cl2 (5 mL) was added trifluoroacetic acid (2.0 mL, 27.0 mmol). The reaction mixture was stirred at room temperature for 2 h then concentrated to give (R)-3-amino-1-pyrrolidin-1-yl-butan-1-one trifluoroacetate as a pale yellow oil which was used without further purification.

후처리

  1. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-5f47dedac97a4f4d8af977687f9660a6
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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