참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzylamine | HCID 7504 | — |
| 반응물 | 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one | HCID 21865450 | — |
| 시약 | Sodium Methoxide | HCID 10942334 | — |
| 촉매 | 1,2-Bis(diphenylphosphino)ethane | HCID 74267 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one | HCID 67223915 | 0% |
반응 단계
In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-08bf18171af14ad9bb3d94faf7cd7b73 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
