Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| 반응물 | 4-(4-Fluorobenzoyl)piperidine | HCID 2724440 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine | HCID 19690008 | 25% |
반응 단계
4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728835 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-3ff4585334ae4e29b75a677785e6dfac |
| 출처 메모 | uspto-grants-1998_03 |