Acetaldehyde → (S)-N-[(1E)-ethylidene]-2-methylpropane-2-sulfinamide

HRID 246060노트

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HRID 246060 반응식
[CH3:1][C:2]([S@@:5]([NH2:7])=[O:6])([CH3:4])[CH3:3].[CH:8](=O)[CH3:9].[O-]S([O-])(=O)=O.[Mg+2].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH:8](=[N:7]/[S@:5]([C:2]([CH3:4])([CH3:3])[CH3:1])=[O:6])\[CH3:9]

참가 물질

6

반응물 4

HCID 177AcetaldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 11355477tert-Butylsulfinamide, (S)-(-)-

생성물 1

HCID 77058989(S)-N-[(1E)-ethylidene]-2-methylpropane-2-sulfinamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a flask (S)-2-methyl-propane-2-sulfinic acid amide (1.50 g, 12.4 mmol) was dissolved in CH2Cl2 (6 mL). Acetaldehyde (6.25 mL, 111 mmol), MgSO4 (4.47 g, 37.1 mmol) and pyridinium tosylate (156 mg, 0.62 mmol) were added. The reaction mixture was stirred overnight at room temperature, filtered and concentrated to give (S)-2-methyl-propane-2-sulfinic acid (E)-ethylideneamide as a pale red oil which was used without further purification.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ab8e54b477a54be58970a62ff32565e8
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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