Trifluoroacetic acid → (R)-2-amino-1-((S)-3-fluoro-pyrrolidin-1-yl)-propan-1-one trifluoroacetate

HRID 246090노트

반응식

HRID 246090 반응식
C(OC(=O)[NH:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:15][CH2:14][C@H:13]([F:16])[CH2:12]1)=[O:10])(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:15][CH2:14][C@H:13]([F:16])[CH2:12]1)=[O:10]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71279860[(R)-2-((S)-3-fluoropyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 71280348(R)-2-amino-1-((S)-3-fluoro-pyrrolidin-1-yl)-propan-1-one trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

[(R)-2-((S)-3-Fluoro-pyrrolidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (43 mg, 0.127 mmol) was dissolved in dichloromethane (1.6 ml) and cooled in an ice bath. Trifluoroacetic acid (0.8 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (R)-2-amino-1-((S)-3-fluoro-pyrrolidin-1-yl)-propan-1-one trifluoroacetate which was used without further purification.

후처리

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-a9ca333576004d9e87ae8db7e29043a4
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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